<p>RT 2 will create a fundamental materials science approach to study stimuli-responsive smart biomaterials and cell-free bioprogrammable materials, filling a void in the bioinspired biomaterials research field. Combining experimental investigations with computer simulations, three phase transition phenomena under different stimuli will be probed: (i) pH-triggered conformational change in polydiacetylene-peptide; (ii) glutathione-stimulated morphological change in polyurethane polymer nanoparticles; and (iii) AC magnetic field-activated phase transition, from hydrophobic to hydrophilic, in polymeric nanocomposites containing superparamagnetic iron oxide nanoparticles. The design guidelines accruing from this project will facilitate the development of a range of bioinspired materials, but also other new polymeric biomaterials.</p>